Retatrutide 5 mg — reference profile

What this compound is

Retatrutide is a synthetic peptide that binds three receptors — GLP-1, GIP and glucagon — rather than one. That combination is what distinguishes it from earlier single- and dual-agonist peptides, and it is the property most of the published work is concerned with.

Molecular profile

Composition: Synthetic triple-agonist peptide (GLP-1 / GIP / glucagon). Molecular weight ≈ 4731 Da.

Molecular weight is the figure used to confirm identity by mass spectrometry: the measured mass is compared against the value calculated from the sequence, and agreement within instrument tolerance is what establishes that the material is the intended molecule rather than merely a pure one.

What published research has examined

Published research has examined receptor binding and selectivity across the three targets, signalling downstream of each, and metabolic endpoints in preclinical and clinical study populations. Interest in the glucagon arm specifically concerns energy expenditure, which the GLP-1 and GIP arms do not address in the same way.

This is a description of what has been studied, not a claim about outcomes and not a suggestion that anyone should use it. Research findings in cell culture or animal models do not transfer directly to any other setting.

Format and handling

Single vial of lyophilized material.

Supplied as a white lyophilized powder. Stored dry, cold and dark it is stable for an extended period; once in solution the usable window is much shorter.

Storage conditions and the expiry date on the label describe material kept as specified. A vial left at ambient temperature has not been stored as specified, whatever the date says.

Documentation and verification

Each batch carries a Certificate of Analysis stating purity, identity and the methods used. The outer box carries a printed RVL code which resolves against production records and returns the item, strength, batch number and dates.

The batch number should read the same on the vial, on the box and on the certificate. Where it does not, treat the material as undocumented until the discrepancy is explained.